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Trulicity (dulaglutide) is not insulin, but rather a kind of diabetic medication known as a GLP-1 analogue. It is a tiny protein (called a peptide) similar to insulin, and because proteins are rapidly broken down by stomach acids, rendering the protein inactive, both insulin and Trulicity (dulaglutide) must be injected beneath the skin. This allows the molecule to enter the body while bypassing the intestines.

Trulicity pens come in 0.75mg and 1.5mg strengths. In general, patients should start on a lesser dose and gradually raise it over 3 to 6 months. This significantly lowers the adverse effects. Many regions only have 1.5mg available.

In the Award 11 Study, 1,842 persons with type 2 diabetes were given weekly dosages of 1.5mg, 3mg, or 4.5mg. Those who took the higher dose had a lower Hb A1c (1.53% for the 1.5 mg dose, 1.71% for the 3 mg dose, and 1.87% for the 4.5 mg dose). The higher the Trulicity dose, the greater the weight reduction, with the highest 4.5mg dose resulting in around 4.7kg weight loss. In the United States, the larger dosages are now FDA-authorized.

Trulicity is given as an injection beneath the skin once a week.

To help you remember when to take your Trulicity, set a weekly reminder on your phone. It makes no difference what day of the week Trulicity (Dulaglutide) is administered on, thus it is better to select a day that matches a person’s lifestyle. For example, you may pick Sunday to administer Trulicity. You may set a recurring alarm in your phone to remind you. You administer it once a week on Sundays, and that’s it. It’s just that simple!

Trulicity is a really simple and straightforward concept.

1. Remove the cap at the end to protect the needle, which is hidden inside the pen barrel.

2. Apply the pen to your skin.

3. Turn the padlock to the unlock position (the green unlocked padlock).

4. The first click noise you will hear is when you press the button.

5. Keep the pen on your skin for a few seconds until you hear the second click.

6. Dispose of the Trulicity pen – Because the needle retracts back into the pen, you may throw it away in a regular trash can.

You may have seen a red padlocked padlock as well. This is to keep you from accidentally firing the pen when you shouldn’t.

The abdomen is the ideal place for medication administration. Trulicity should only be injected subcutaneously into your upper arm, thigh, or belly. Choose a separate injection location each week when injecting into the same body area, such as your abdomen.

If you miss a dosage of Trulicity, take it as soon as possible within 3 days following the missing dose. After that, you can resume your usual weekly dose plan.

Do not take your missed dosage if it is less than 3 days until your next scheduled dose. Take your next planned weekly dosage and then resume your usual weekly dose!

Trulicity can be given with or without meals. However, it is suggested to avoid certain foods that would increase your blood sugar levels. 

Although Trulicity is a successful therapy for type 2 diabetes, it can have a variety of negative effects.

The following are the most prevalent Trulicity side effects:

• nausea

• vomiting

• diarrhea

• abdominal discomfort

• reduced appetite

Over 10% of Trulicity users may develop these gastrointestinal side effects. The sensation is comparable to what a person feels when they overeat.

Most patients will stop experiencing these gastrointestinal side effects within 8-12 weeks, and dulaglutide is well-tolerated in the long term.

Trulicity has some serious side effects.

Trulicity may potentially result in more significant adverse effects such as:

• pancreatic inflammation

• hypoglycemia

• allergic responses

GLP-1s do not induce thyroid cancer in humans, to put it simply.

Early research found that when rats were given dulaglutide and other GLP-1 medications, many of them developed a highly uncommon and deadly thyroid cancer known as medullary thyroid carcinoma. GLP-1 receptors are abundant in the thyroids of rats. These do not exist in human thyroid cells.

The early fear that GLP-1 causes thyroid cancer prompted intensive research and studies into the topic, and despite millions of individuals being treated with GLP-1 medicines throughout the world, there has been no evidence of a problem. GLP-1 medications such as Trulicity and Victoza (liraglutide) are not indicated if there is a family history of medullary cell carcinoma of the thyroid or Multiple Endocrine Neoplasia Type 2. (MEN 2).

Trulicity is intended for persons with type 2 diabetes. Trulicity, in conjunction with diet and exercise, can assist to improve glycemic management. It is not recommended for patients with type 1 diabetes.

Trulicity is currently not advised for pregnant women. Diabetes in pregnant women is treated with other drugs.

If you have type 2 diabetes and want to create a family or add a new member, it is suggested that your blood glucose levels and HbA1c levels be kept as close to the target goals as feasible before conception and during pregnancy. Your doctor may establish these objectives.

Making lifestyle changes, such as exercising and eating a healthy diet, is critical if you have type 2 diabetes.

Yes. If you have extra Trulicity injectable pens at home, keep them in the fridge.

The top shelf of the fridge door is the perfect spot to keep your Trulicity pens. The butter container is typically the most secure. Trulicity pens should not be kept in the coldest region of your refrigerator. If the Trulicity injectable pen becomes too cold, the Dulaglutide degrades and becomes less effective, resulting in increased blood glucose levels.

Yes, Trulicity can be injected cold, however it may cause some discomfort. It is still useful.

Bydureon (Exenatide Extended Release) is a weekly GLP-1 that should not be administered cold since it requires extensive mixing.

Trulicity (Dulaglutide) may take up to 5 weeks to begin decreasing your blood glucose levels, but the full benefit will not be visible for 3-6 months.

If a person uses Trulicity for a few months and then discontinues it, it will take roughly 5 weeks to clear the system fully. In general, if a medicine is used daily, it takes 5 days to reach a stable level and another 5 days to empty the system. If a medicine is given once a week, it takes 5 weeks to enter the body and 5 weeks to clear.

Yes. Trulicity can produce weight loss, however, it is not a weight loss medication.

A number of studies have been conducted to investigate the efficacy of Trulicity (Dulaglutide) in the treatment of type 2 diabetes. These AWARD studies also looked at the concomitant weight reduction in Trulicity patients. Trulicity was shown to be more successful in producing weight reduction than another type 2 diabetes medicine called sitagliptin in one of the AWARD trials, Efficacy and Safety of Dulaglutide Versus Sitagliptin After 52 Weeks in Type 2 Diabetes in a Randomized Controlled Trial (AWARD-5) (a DPP-4 inhibitor). The average change in body weight was 2.6kg (with Trulicity 0.75mg weekly dosage) and 3kg (with Trulicity 1.5mg weekly dose).